• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    4-Acyloxyazetidinones (I):… …<IMAGE>… [wherein R1 and R2 represent a hydrogen atom or a protecting group and R3 represents a C1-C10 alkyl or an aryl group] are prepared by oxidation of compounds of formula (II> …<IMAGE>… [wherein R1, R2, and R3 are as defined above] in a two-phase system comprising: … … a) an organic phase comprising a 4-acylazetidinone compound (II) and an "onium" salt (eg quaternary ammonium or phosphonium salt) dissolved in a medium immiscible with water and … b) an aqueous phase comprising an alkali or alkaline-earth metal salt of an organic or inorganic peracid. … …<??>The 4-acyloxyazetidinones (I) are useful intermediates in the synthesis of anti-bacterial compounds.
    公开号:SU1588279A3
    申请号:SU874203489
    申请日:1987-10-13
    公开日:1990-08-23
    发明作者:Риччи Марко；Альтамура Мария；Боянки Даниель；Кабри Вальтер；Гатти Норберто
    申请人:Фармиталиа Карло Эрба, С.П.А. (Фирма)；
    IPC主号:
    专利说明:

    This invention relates to organic chemistry, in particular to an improvement in the process for the preparation of the 4-acyloxyazetidinone derivative of formula I OH o.
    H-jC
    /
    cI
    with -
    eleven
    about
    x °
    -sn% h
    used as an intermediate in the preparation of substances with anti-bacterial properties, which are called foams.
    The purpose of the invention is to simplify the process.
    Example 1. In a two-neck two-neck flask with a capacity of 50 ml, equipped with a thermometer, deflector and magnetic mixers.
    Yoy, loaded with 440 mg of (3S, 4S) -4-ben-: foil-3 (1 K) -oxyethyl. -azetidin-2-one (2 mmol), 3.5 ml of ethyl acetate, 50 mg of fmichi dimethyl-dioctadecyl J-ammonium-g of zlorsoride (75% w / w) and 25% w / w dimethyl-dihexadecyl-ammonium chloride about 0, 1 mmol), 14 ml of 1-phosphate phosphate as a buffer at pH 6.6 I, 1.47 tons of a mixture containing 41.5% of first potassium sulfonate (4 mmol}, as well as KHSO and. The mixture was heated
    After vigorous stirring to 40 ° C, I was held at this temperature for 9 hours. At the end of this period, the 15 phases were separated and the organic phase was washed with a saturated bicarbonate solution and brine, dried over anhydrous sodium sulfate, filtered and evaporated. Thus, 310 mg of a yellowish solid was obtained in 20 times after washing with pentane, 273 mg / 3R, 43) -4-benzoyloxy-3 (1K) -oxyethylJ-azetidin-2-one was obtained (yield 58%), tlsh. 25 1149-151 С (crystals from a mixture of ethyl 1-acetate-pentane). .
    o (g) + 101 ° (s 1, methanol). H-NMR (CBCI3, 300 MHz), cG: 1.38 (ZN, doublet), 3.11 (1H, broad), GD 3.39 (IH, double doublet, J 1.1 and 6.5 Hz) , 4.28 (1H, multiplet) ,, 6.11 (1H, doublet, J 1.1 Hz), 7.17 (1H, broad), 7.47, 7.62 and 8.05 (5I, triple multiplet) .35 Mass spectrum (C.1 isobuvdn), t / e
     235 (M).
    Example 2. The procedures of Example .1 were repeated, replacing 2KHS05-KHSO xKiS04 with 1.98 g of acidic magnesium monoperoxyphthalate hexahydrate (4 mmol) using 20 ml of sodium phosphate in quality buffer at pH 6.6 and increasing the reaction time to 10%. h
    Thus, 264 mg of (3R, 43) -4-benzoyloxy-3- (1K) -oxyethyl-Jazetidin-2-one was obtained (yield 56%).
    Example 3 (comparative). In a 50 ml two-necked flask equipped with a thermometer, a reflux condenser and a magnetic stirrer, 440 mg (35.45) -4-benzoyl-3- (1K) -oxyethyl-azetidin-2-mna (2 mmol), 10 ml x were loaded. pororoform and 1.53 g of 90% m-chloroperobenzoic acid (8 mmol) and the resulting solution was stirred for 60 hours at room temperature. The solution was then washed with saturated aqueous solutions of sodium meta-bisulfite, sodium bicarbonate and sodium chloride, dried over anhydrous calcium chloride, filtered and evaporated. Thus, 180 mg of pure (3R, 45) -4-benzoyloxy-3- (1K) -oxyethyl-azetidin-2-one was obtained (yield 38%).
    Example 4. Analogously to Example 1, replacing the mixture of dime. Tyl-fiocta-decyl} -ammonium chloride, i-dimethyl-dihexadecyl-ammonium chloride to 34.0 mg tetrabutylammonium bisulfate (0.1 mmol). 259 mg of (3R, 4S) 4-benzoyloxy-3- (III) -oxyethyl-azethidin-2-one are obtained (yield 55%).
    Example 5. Analogously to example 1, replacing a mixture of dimethyl- (diocta-decyl-ammonium chloride and ;;;; 1 methyl-dihexadecyl-ammonium chloride with 40.4 mg methio; 1 trioctylammonium chloride (0.1 mmol
    240 mg of (3R, 43) -4-benzo-yloxy-3- (III) -oxyethyl} -azetidin-2- one is obtained (yield 50%).
    Example 6. Analogously to Example 1, using 10 mg (approximately 0.02 mmol) of a mixture of 75% dimethyl-dioxtadecyl-ammonium chloride and 25% dimethyl-dihexadecyl J-ammonium chloride, which corresponds to 0.01 mol of acid
    salts per 1 mole of compound II.
    259 mg of (3R, 45) -4-benzo-yloxy-3-C (1R) -oxoxyl-azetidin-2-one is obtained (yield 55%).
    Example 7. Analogously to Example 1, using 14 ml of sodium phosphate buffer pH 6.0.
    230 mg of (3R, 45) -4-benzo-yloxy-3- (1R) -oxyethyl} -azetidin-2-one is obtained (yield 49%).
    Example 8. Analogously to Example 1, using 14 ml of sodium phosphate buffer pH 8.0.
    140 mg of (3R ,, 43) -4-benzo1-1l hydroxy-3- (1K) -oxyethyl 11-azetidin-2-one is obtained
    (yield 30%).
    From the presented results, the advantages of using the proposed method as peracid salts in the two-phase system as an oxidizer are obvious. Compared with the peracids used in the known (SM method, salt oxidizers are stable, they can be stored for a long time, however, they are easier to separate from the reaction product. In addition, the organic peracids used in the known method do not allow to obtain satisfactory results after .d
    51
    increase the acidity of the medium during their recovery. This leads to the necessity of introducing protective groups with good stability in the presence of acids into the starting compound of general formula II. as a result, an additional step is required to remove the protective groups.
    权利要求:
    Claims (1)
    [1]
    Thus, the proposed method greatly simplifies the oxidation process. Salt oxidizers make the reaction safe, and by reducing the corrosive effects of the environment, the costs of manufacturing the equipment are reduced. Invention Formula
    The method of obtaining (3R, 48) -4-benzoyloxy-3- (1R) -oxyethyl J-azevtindin-2-one of formula I
    Nz
    about
    by the interaction of (3S, 45) -4-benzoyl-3-C (1R) -oxyethyl} -azetidin-2-one of formula IIOH
    ten
    with a peroxide, characterized in that, in order to simplify the process, the peroxide is a salt of an alkaline or alkaline earth metal of an organic or inorganic peracid and the process is carried out in a two-phase system which includes an organic phase which is a solution in ethyl acetate 2-25% by weight of (3S, 45) -4-benzoyl-3 LdR) -oxyethylazetidin-2-one and an onium salt selected from the group: 75% by weight of dimethyl (dioctademic) ammonium-5 chloride with 25% by weight of dimethyl (dihexade-CSH1) ammonium chloride, tetrabutylammonium bisulfate or methyl trioctyl and mmonicheloride in an amount of 0.01-0.1 mmol / mol of the starting ketone of formula II, and an aqueous phase containing 3.9-9% by weight of peracid salt selected from the group: potassium peroxyimonosulfate, acidic hexahydrate monoperoxy phthalate magnesium or 2KHSO. KKS04-KJSO and sodium phosphate buffer to maintain the pH of an aqueous solution of 6-8 and the reaction is carried out at 30 ° C-30 ° C for 9-10 hours.
    0
    SN with
    NCS n-h
    сNH
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    同族专利:
    公开号 | 公开日
    US5043440A|1991-08-27|
    ATA268387A|1990-12-15|
    FI874471A|1988-04-16|
    PT85914A|1987-11-01|
    NZ222112A|1990-02-26|
    FI88294C|1993-04-26|
    GB8724099D0|1987-11-18|
    FI88294B|1993-01-15|
    AU592231B2|1990-01-04|
    GB2196340B|1990-05-02|
    JPS63112559A|1988-05-17|
    BE1000617A4|1989-02-21|
    GB2196340A|1988-04-27|
    IT1197873B|1988-12-21|
    GR871558B|1988-02-23|
    IT8622003D0|1986-10-15|
    DE3734468A1|1988-04-28|
    AT392965B|1991-07-25|
    FR2605318B1|1991-04-19|
    HU200325B|1990-05-28|
    DK533287A|1988-04-16|
    FI874471A0|1987-10-12|
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    PT85914B|1990-08-31|
    SE8704000L|1988-04-16|
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    CH676983A5|1991-03-28|
    IL84149A|1991-09-16|
    FR2605318A1|1988-04-22|
    ZA877683B|1988-06-29|
    CA1325638C|1993-12-28|
    IL84149D0|1988-03-31|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    DE2724675A1|1977-06-01|1978-12-14|Bayer Ag|TETRAHYDROFURAN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS HERBICIDES|
    US4742052A|1981-07-15|1988-05-03|Sumitomo Pharmaceuticals Company, Limited|Antibacterial β-lactam compounds|
    GB8321004D0|1983-08-04|1983-09-07|Erba Farmitalia|Azetidinones|
    JPS6061566A|1983-09-14|1985-04-09|Sankyo Co Ltd|Production of 4-acetoxyazetidinone derivative|
    EP0181831B1|1984-10-01|1993-08-25|Ciba-Geigy Ag|Process for the preparation of optically active acyloxyazetidinones|
    EP0221846A1|1985-10-28|1987-05-13|Ciba-Geigy Ag|Optically active acyloxyazotidinones|
    US4882429A|1986-03-03|1989-11-21|Schering Corporation|Stereospecific preparation of -3--4-benzoyloxy-azeridinones from L--theonine|AU601180B2|1986-04-30|1990-09-06|Kanegafuchi Kagaku Kogyo Kabushiki Kaisha|Process for preparing 4-acetoxy-3-hydroxyethylazetidin -2- one derivatives|
    JP2608458B2|1988-05-19|1997-05-07|日本曹達株式会社|Method for producing 4-acetoxyazetidinone derivative|
    US5204460A|1988-11-29|1993-04-20|Takasago International Corporation|Ruthenium catalyzed process for preparing 4-acetoxyazetidinones|
    US5068232A|1990-04-10|1991-11-26|American Cyanamid Company|Novel 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    IT22003/86A|IT1197873B|1986-10-15|1986-10-15|PROCEDURE FOR THE PREPARATION OF AZETIDINONES|
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